Efficacy and Safety of Lianhua Qingwen Preparation in Treatment of Community-acquired Pneumonia：A Systematic Review and Meta-analysis
10.13422/j.cnki.syfjx.20241697
- VernacularTitle:连花清瘟制剂治疗社区获得性肺炎疗效及安全性的系统评价和Meta分析
- Author:
Yanxiang HA
1
;
Xin LIU
2
;
Shiwei KANG
2
;
Shuo WANG
1
Author Information
1. Beijing Hospital of Traditional Chinese Medicine，Capital Medical University，Beijing 100010，China
2. The Second Hospital of Hebei Medical University，Shijiazhuang 050000，China
- Publication Type:Journal Article
- Keywords:
Lianhua Qingwen preparation;
community-acquired pneumonia;
antibiotic treatment;
efficacy;
safety;
systematic review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(13):142-149
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the efficacy and safety of Lianhua Qingwen preparation in the treatment of community-acquired pneumonia （CAP）. MethodThe PubMed，Embase，Cochrane Collaboration，CNKI，VIP，and Wanfang Medical Network database （CBM） were systematically searched for all the randomized controlled clinical trials （RCTS） of Lianhua Qingwen Preparation in the treatment of CAP from the establishment of the databases to February 2023. The inclusion criteria were established， and the search results were screened. The risk assessment tool （ROB） scale was used to evaluate the methodological quality of the final included studies， and the R software was used for data integration and meta-analysis. ResultA total of 30 pieces of literature were included，involving 2 800 patients. The combined use of Lianhua Qingwen preparation on the basis of antibiotics and other conventional treatments showed that Lianhua Qingwen preparation could improve the cure rate ［relative risk（RR）=1.32，95% confidence interval（95% CI）［1.23，1.42］，P<0.000 1）］ and shorten the time of fever remission ［Mean difference（MD）=-1.45，95% CI ［-1.93，-0.97］，P<0.000 1］，and the duration of fever reduction was divided into general population and special population subgroups. The results showed that Lianhua Qingwan preparation could shorten the duration of fever reduction （general population MD=-1.51，95%CI ［-2.07，-0.94］，P<0.000 1， special population MD=-1.22，95% CI ［-2.16，-0.29］，P=0.010 6）and does not increase the incidence of adverse reactions（RR=0.85，95%CI ［0.62，1.15］，P<0.000 1）. After nine pieces of virtual literature with negative results were supplemented by the shear compensation method，the cure rate of CAP by Lianhua Qingwan preparation was still improved （RR=1.20，95%CI ［1.13，1.29］，P<0.000 1）. ConclusionThe application of Lianhua Qingwen preparation on the basis of antibiotics in the treatment of CAP can improve the cure rate and shorten the time of fever reduction.
