Conceptual Framework of A Next-generation General-purpose Clinical Scientific Disease Database
10.3971/j.issn.1000-8578.2024.23.1224
- VernacularTitle:下一代通用型临床科研专病数据库的建设理念框架思考
- Author:
Min PENG
1
;
Qianru CHEN
;
Kai CHEN
Author Information
1. 510120 广州,中山大学孙逸仙纪念医院广东省恶性肿瘤表观遗传与基因调控重点实验室;510120 广州,中山大学孙逸仙纪念医院随访中心
- Keywords:
Specialized disease data;
Data management;
Clinical research database;
Database construction;
Breast cancer
- From:
Cancer Research on Prevention and Treatment
2024;51(5):321-327
- CountryChina
- Language:Chinese
-
Abstract:
Empowered by the rapid development of artificial intelligence technology and information security technology,basic medicine,translational medicine,and clinical medicine have entered a new era.In this process,the relevant data such as text,genetics,images,and videos have increased at an astonishing rate.Traditional specialized disease databases cannot adapt to the multimodality of data and the multicentralization of data sources in the present/future.Therefore,establishing a next-generation multimodal and multicenter collaborative specialized disease database that is suitable for secure data sharing and ethical in clinical research is essential.This paper expounds the concept and basic framework of developing a next-generation clinical research disease database with universal use,emphasizing the establi-shment of a multimodal data integration mechanism,a multicenter collaborative system supported by privacy-preserving computing,highly intelligent software and hardware entities,and an integrated operational management mode.It also introduces the application of this conce-pt in the construction of a breast cancer three-dimensional life database,a proje-ct of China Breast Cancer Innovation Alliance.
