Construction and Verification of Quality Evaluation Indicator System for Extracorporeal Membrane Oxygenation Animal Experimental Platform
10.12300/j.issn.1674-5817.2023.107
- VernacularTitle:体外膜肺氧合动物实验平台质量评价指标体系的构建与验证
- Author:
Shuo WANG
1
;
Yunhui LÜ
1
;
Xiaokang WANG
1
;
Zhenhao ZHANG
1
;
Yongchun CUI
1
Author Information
1. Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials; State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases; Animal Experimental Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102800, China
- Publication Type:Journal Article
- Keywords:
Extracorporeal membrane oxygenation;
Animal experimental platform;
Quality evaluation
- From:
Laboratory Animal and Comparative Medicine
2023;43(6):604-611
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo establish a standardized and professional service quality evaluation index system for extracorporeal membrane oxygenation (ECMO) animalexperimental platform.Methods The literature research and expert consultation were used to establish a factor set for the quality evaluation of ECMO animal experimental platform. Then, experts used the 1/9-9 scale method to compare and score pair-two indicators. Based on the principles of fuzzy analytic hierarchy process and expert scoring results, the ECMO animal experimental platform quality evaluation system was constructed. In order to verify the actual efficacy of this system, a case study was carried out on the ECMO animal experiment platform of FW Animal Experimental Center (FAEC) laboratory.Results A total of 10 experts were included in this study, the questionnaire recovery rate was 100%, the judgment coefficient (Ca) and familiarity coefficient (Cs) were both greater than 0.50, the expert authority was high (Cr>0.80), the validity test was P<0.01, and the coordination was good. The quality evaluation system of ECMO animal experiment platform includes two levels. There are 4 first-level indicators, with professionalism, safety, functionality, and stability ranked from high to low in terms of their weights. There are 15 second-level indicators, and the top 5 weights are personnel's technical expertise, attractiveness of hardware facility, auditability of data, confidentiality capabilities of data, and professionalism in service process. To facilitate the popularization and application of the system, this study also proposed a "star" system to represent the evaluation results of an ECMO animal experimental platform quality. The quality evaluation system established in this study was used to evaluate the FAEC laboratory as a case study, and the evaluation result was five-star. The actual potency value of FAEC laboratory was 0.910, reaching the five-star level, but the average actual appraisal valuesof "service continuity" and "sufficiency of project completion" were lower than 0.80, which needs to be improved.ConclusionA standardized and professional ECMO animal experimental platform quality evaluation system was established in this study, which would provide a measurable basis for the demander to select the supplier and a method for the supplier to complete the animal experiment of ECMO research and development with high quality.
