Effects of Ulinastatin on inflammatory response, hemodynamics, PaO2/FiO2 and prognosis in patients with septic shock
10.12206/j.issn.2097-2024.202206091
- VernacularTitle:乌司他丁对感染性休克患者炎症反应、血流动力学、PaO2/FiO2及预后的影响
- Author:
Xiaodan WANG
1
;
Xiaolong MA
1
;
Wenxing DONG
1
Author Information
1. Department of Pharmacy, Beidaihe Rehabilitation and Recuperation Center of the PLA, Qinhuangdao 066100, China.
- Keywords:
septic shock;
Ulinastatin injection;
hemodynamics;
mortality rates
- From:
Journal of Pharmaceutical Practice and Service
2022;40(6):576-579
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of Ulinastatin injection on inflammation, hemodynamics, oxygenation index (PaO2/FiO2) and prognosis in patients with septic shock. Methods A retrospective analysis was performed on clinical data of 109 patients with septic shock from January 2017 to December 2019. Patients were divided into observation group (n=73) and routine group (n=54) according to the treatment regimens. The two groups were given anti-shock treatment according to the relevant guidelines, and observation group was additionally given Ulinastatin. The inflammatory factors, hemodynamic parameters and PaO2/FiO2 and recovery were compared between the two groups before and after treatment. Results The levels of IL-6, TNF-α and PCT at 7 d of treatment were significantly decreased in the two groups (P<0.05), and the levels of IL-6, TNF-α and PCT of observation group were lower than that of routine group (P<0.05). At 12 h, 24 h and 72 h of treatment, the MAP, CI and PaO2/FiO2 were significantly increased in the two groups (P<0.05) while the EVLWI and SVRI were significantly decreased (P<0.05), and the MAP and PaO2/FiO2 of observation group at the same time were higher than that of routine group while the EVLWI was lower than that routine group (P<0.05). At 7 d of treatment, the APACHE-II score, mechanical ventilation time and ICU stay time of observation group were lower than that of routine group, and the incidence rates of MODS in the two groups were 4.11% and 14.81% respectively (P<0.05), and the mortality rates were 1.37% and 7.41% respectively (P>0.05). Conclusion Ulinastatin could be beneficial in septic shock, which could reduce inflammatory response, improve hemodynamic parameters and microcirculation perfusion, and put a positive effect on promoting rehabilitation and improving prognosis.
