From basic to clinical:Advances in research on ETV1
10.3781/j.issn.1000-7431.2023.2210-0751
- VernacularTitle:从基础到临床:ETV1研究进展
- Author:
Xu-Dong QIU
1
;
Hui CAO
;
Lin TU
Author Information
1. 上海交通大学医学院附属仁济医院胃肠外科,上海 200127
- Keywords:
ETV1;
Neoplasms;
Tumor biomarker;
Molecular targeted therapy
- From:
Tumor
2023;43(8):662-671
- CountryChina
- Language:Chinese
-
Abstract:
ETS variant gene 1(ETV1)is an oncogene that plays an important role in embryonic development and malignant progression of tumors.Chromosomal translocations,gene amplifications,and activation of the mitogen activated protein kinase(MAPK)signal pathways lead to the up-regulation of ETV1,and then ETV1,as a transcription factor,regulates the expression of downstream target genes by binding to their promoters or enhancers,thereby playing a pivotal role in the occurrence and development of prostate cancer,gastrointestinal stromal tumor(GIST)and breast cancer.ETV1 is also a potential tumor biomarker,which has clinical value in diagnosis and prognostic evaluation in various tumors,and strategies targeting ETV1 can provide new treatment options to tumor patients.This article discusses the mechanisms of ETV1 activation and pro-oncogenic mechanisms driven by ETV1,and summarizes and prospects the clinical application of ETV1 as a tumor biomarker and therapeutic target.
