Efficacy of intense pulsed light in treatment of rosacea: a Meta analysis
10.3760/cma.j.issn.1671-0290.2024.01.006
- VernacularTitle:强脉冲光联合药物治疗玫瑰痤疮的Meta分析
- Author:
Yueying LI
1
;
Xinyu CHANG
;
Liwen WANG
Author Information
1. 陕西中医药大学附属医院皮肤科，咸阳 712000
- Keywords:
Rosacea;
Intense pulsed light;
Minocycline;
Tetracycline;
Hydroxychloroquine sulfate;
Ivermectin cream;
Meta-analysis
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2024;30(1):29-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the therapeutic effect of intense pulsed light on rosacea.Methods:From December 2022 to April 2023, the Dermatology Department of the Affiliated Hospital of Shaanxi University of Chinese Medicine searched PubMed, Embase, Cochrane Library, CNKI, Wanfang, VIP, CBM and other Chinese and English databases to collect clinical randomized controlled studies on intense pulsed light treatment of rosacea for ameta-analysis.Results:A total of 559 patients were included in 6 randomized controlled trials. The efficacy of the combination of strong pulsed light and medication in the treatment of rosacea was significantly better than that of medication alone ( Z=6.15, P<0.001). After subgroup analysis, the combination of strong pulsed light and tetracycline drugs was more effective in treating rosacea than using tetracycline drugs alone ( Z=3.17, P<0.05). The efficacy of the combination of strong pulsed light and minocycline in the treatment of rosacea was better than that of minocycline alone ( Z=2.37, P<0.05), and clinical evaluation showed the improvements of erythema, papules, and pustules. The differences in scores for itching and capillary dilation were statistically significant ( P<0.05). Conclusions:The efficacy of intense pulsed light therapy for rosacea is definite, and its combination with topical or oral medication is superior to that of medication alone. However, the stability of the effect needs to be confirmed by more high-quality randomized controlled trials.
