Biofluid biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behavior disorder
10.3760/cma.j.cn114452-20231024-00228
- VernacularTitle:特发性快动眼睡眠行为障碍转化α-突触核蛋白病的体液标志物研究进展
- Author:
Yajie ZANG
1
;
Wei MAO
Author Information
1. 首都医科大学宣武医院神经内科，北京 100053
- Keywords:
alpha-Synuclein;
Marker;
Body fluid
- From:
Chinese Journal of Laboratory Medicine
2024;47(2):187-191
- CountryChina
- Language:Chinese
-
Abstract:
Isolated rapid-eye-movement sleep behavior disorder (iRBD) is considered to be a prodromal stage of α-synucleinopathies, providing an important period for investigating biomarkers of conversion risk and potentially disease-modifying intervention. Many previous studies investigating biomarkers in patients with iRBD have focused on different domains including clinical, body fluid and imaging. Due to their direct response to the pathological changes of brain and advantaged accessibility, body fluid markers have become promising potential biomarkers. These studies have involved different molecules related to different pathogenic mechanisms with poor consistency of results. In this paper, a review of previous work on body fluid markers in patients with iRBD is presented.
