Present view in understanding of polypoidal choroidal vasculopathy
10.3760/cma.j.cn511434-20240103-00001
- VernacularTitle:现在如何认识息肉样脉络膜血管病变
- Author:
Zhizhong MA
1
Author Information
1. 北京大学第三医院北京大学眼科中心，北京 100191
- Keywords:
Polypoidal choroidal vasculopathy;
Age-relatedmaculardegeneration;
Histopathology;
Ultrastructure;
Editorial
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(2):89-97
- CountryChina
- Language:Chinese
-
Abstract:
Polypoidal choroidal vasculopathy (PCV) is originally defined as a separate disease, but with the development of imaging techniques, it has now been included in the spectrum of neovascularization. In the Asian population, the prevalence of PCV is high, and with the deepening of clinical studies, the pathological characteristics, pathogenesis and clinical manifestations of PCV have been more deeply understood. Through dynamic observation and histopathological study of PCV lesions during operation, it can be confirmed that the lesions are mainly located between the retinal pigment epithelium and the Bruch membrane, rather than originating from the choroidal circulation, which is of great significance for understanding the origin and natural course of PCV. It is worth noting that although a theoretical bridge has been established between age-related macular degeneration (AMD)/PCV, there is a lack of intuitive clinical data on the ultrastructural and molecular manifestations of the cells/stroma in the local lesions of the eye, especially the progression of AMD/PCV from early/middle stage to exudative stage. It is precisely because of this that highly attractive research topics and exploration space are proposed for the future.
