Cases analysis and etiology discussion of thymoma with alopecia areata
10.3760/cma.j.cn112434-20230509-00104
- VernacularTitle:胸腺瘤合并斑秃的病例分析及病因探讨
- Author:
Ying ZHANG
1
;
Dingfang CAO
;
Lei YU
;
Xintao YU
;
Jian CUI
;
Xin DU
Author Information
1. 首都医科大学附属北京同仁医院病理科，北京 100730
- Keywords:
Thymoma;
Alopecia areata;
Autoimmune disease;
CD8 + T lymphocyte
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2024;40(2):105-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Analyzed the clinicopathological features of thymoma with alopecia areata, and discussed the pathogenesis and treatment methods.Methods:The clinicopathologic data of patients with thymoma who underwent surgery from August 1, 2015 to July 31, 2020 in Beijing Tongren Hospital, Capital Medical University were reviewed. Transversally analyzed the patients of thymoma with alopecia areata and longitudinally compared with the patients of thymoma without alopecia areata after 1﹕10 matched by propensity score matching.Results:A total of 252 patients of thymoma were enrolled, including 6 patients with alopecia areata, accounting for 2.38%. The anti-AchR antibody, CD4 + /CD8 + T inversion in serum and myasthenia gravis were present in the all 6 thymoma patients with alopecia areata, which were significantly higher than those in the group of thymoma without alopecia areata. Besides myasthenia gravis, the proportion of complicated with other autoimmune diseases in thymoma patients with alopecia areata was significantly higher than that of thymoma patients without alopecia areata[83.33%(5/6) vs. 20.00%(12/60), P=0.003]. After operation, 5 patients’ alopecia areata were improved in 6 thymoma patients with alopecia areata(83.33%, 5/6). Conclusion:The thymoma patients with alopecia areata always complicated with myasthenia gravis and other autoimmune diseases. The pathogenesis may be associated with autoimmune CD8 + T lymphocytes produced by thymoma. At present, surgery is still the most effective way to improve thymoma-associated alopecia areata.
