Advances in animal models of influenza A virus infection
10.3760/cma.j.cn112309-20230327-00073
- VernacularTitle:甲型流感病毒感染动物模型的研究进展
- Author:
Yifei WANG
1
;
Weijin HUANG
;
Yansheng GENG
;
Chenyan ZHAO
Author Information
1. 中国食品药品检定研究院艾滋病性病病毒疫苗室，国家卫生健康委员会生物技术产品检定方法与标准化重点实验室，国家药品监督管理局生物制品质量研究与评价重点实验室，北京 102629
- Keywords:
Influenza A virus;
Animal model;
Advantages and limitations;
Infection;
Vaccine
- From:
Chinese Journal of Microbiology and Immunology
2023;43(9):727-732
- CountryChina
- Language:Chinese
-
Abstract:
Influenza has caused high morbidity and mortality worldwide, seriously endangering human health and life. The continuous mutation of influenza virus has brought new challenges to the prevention and treatment of influenza. Animal models provide convenience for a comprehensive understanding of influenza virus pathogenesis, transmission mechanism, vaccine development, and evaluation of therapeutic effects. The construction and use of animal models of influenza virus infection vary in different studies, and the application of different animal models also has its own characteristics. This article reviewed the current status of the construction and use of various animal models, and summarized the advantages and limitations of animal models in evaluating the efficacy of antibodies, drugs and vaccines, with the aim of providing reference for the selection and optimization of animal models in the future.
