Chemical constituents from Ganoderma angustisporum and their α-glucosidase inhibitory activities
10.3969/j.issn.1001-1528.2024.01.023
- VernacularTitle:窄孢灵芝化学成分及其α-葡萄糖苷酶抑制活性研究
- Author:
Ya-Qin HUO
1
;
Yu-Xi WANG
;
Yu-Lian WEI
;
Yi-Xuan ZHANG
;
Hai-Sheng YUAN
Author Information
1. 沈阳药科大学生命科学与生物制药学院, 辽宁 沈阳 110016;中国科学院沈阳应用生态研究所,中国科学院森林生态与管理重点实验室, 辽宁 沈阳 110016
- Keywords:
Ganoderma angustisporum J.H.Xing,B.K.Cui&Y.C.Dai;
chemical constituents;
isolation and identification;
α-glucosidase inhibitory activities
- From:
Chinese Traditional Patent Medicine
2024;46(1):132-137
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Ganoderma angustisporum J.H.Xing,B.K.Cui&Y.C.Dai and their α-glucosidase inhibitory activities.METHODS The ethyl acetate extract from G.angustisporum was isolated and purified by silica gel,ODS,TLC and HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.pNPG method was used to evaluate their α-glucosidase inhibitory activities.RESULTS Seven compounds were isolated and identified as N-acetyl-L-phenylalanine ethyl ester(1),N-acetyl-L-phenylalanine methyl ester(2),4-hydroxy-17R-methylincisterol(3),6,8-di-O-methylaverufin(4),aversin(5),methyl 2-(4-hydroxyphenyl)aceate(6),5-toluene-1,3-diol(7).Compounds 1-2,4-7 showed inhibitory activities of α-glucosidase with IC50 values being(33.80±0.47),(45.45±7.95),(48.80±5.86),(39.48±2.82),(41.47±6.68),(55.38±10.12)μmol/L,and compound 1 showed good inhibitory activity.CONCLUSION Compound 1 is a new natural product.Compounds 2-7 are isolated from genus Ganoderma for the first time.Compounds 1-2,4-7 have α-glucosidase inhibitory activities.
