Androgenic granulosa cell tumor of ovary: a case report and literature review

VernacularTitle:一例分泌雄激素的卵巢颗粒细胞瘤病例报道并文献复习
Author: Xiaoyu HE ¹ ; Xi CHEN ; Tianming XIE ; Junhui XIE
Author Information

1. 华中科技大学同济医学院附属同济医院内分泌内科，国家代谢性疾病临床医学研究中心分中心，武汉　430030
Keywords: Granulosa cell tumor of ovary; Polycystic ovarian syndrome; Hyperandrogenism
From: Chinese Journal of Endocrinology and Metabolism 2023;39(12):1080-1082
CountryChina
Language:Chinese
Abstract: This article reports a case of oligomenorrhea accompanied by acne over several years. The patient presented with hyperandrogenism and insulin resistance. The initial diagnosis considered polycystic ovary syndrome(PCOS) and was treated with oral medication for 2 months, with no significant improvement. Further ultrasound examination revealed a right ovarian heterogeneous mass (3.2 cm×3.0 cm). The patient underwent laparoscopic resection of the right ovarian lesion. Postoperative pathology revealed ovarian sex cord-stromal cell tumor, adult granulosa cell tumor(diffuse type). Testosterone levels decreased to the normal 3 days after the surgery, and menstruation resumed within 2 months. This article summarizes the presented case and reviews the relevant literature. For women with severe hyperandrogenism and masculinization, it is recommended to thoroughly assess the possibility of androgen-secreting tumors.