Correlation of serum and follicular fluid SREBP1c and LRG1 levels with insulin resistance in PCOS patients
10.3760/cma.j.cn311282-20230602-00246
- VernacularTitle:多囊卵巢综合征患者血清、卵泡液固醇调节元件结合蛋白1c、富含亮氨酸的α-2-糖蛋白1水平的变化及与胰岛素抵抗的相关性研究
- Author:
Xiaoting GUI
1
;
Qi HUANG
;
Xiaoying YUAN
;
Yachao BA
;
Yu LI
;
Xiying ZHANG
;
Qian WANG
;
Lin ZHANG
;
Han ZHANG
;
Ying ZHANG
;
Xin LIAO
Author Information
1. 遵义医科大学附属医院内分泌与代谢病科，遵义 563000
- Keywords:
Polycystic ovary syndrome;
Insulin resistance;
Sterol regulatory element binding protein 1c;
Leucine-rich α-2-glycoprotein 1
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(11):937-943
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the serum and follicular fluid levels of sterol regulatory element-binding protein 1c(SREBP-1c), leucine-rich α-2-glycoprotein 1(LRG1) and the correlation with insulin resistance(IR) in non-ovarian etiology infertility patients and polycystic ovary syndrome(PCOS) patients with or without IR.Methods:Forty-nine PCOS patients and 66 infertility patients with non-ovarian etiology were collected in this retrospective study, homeostasis model assessment for insulin resistance(HOMA-IR) was used to evaluate IR, and were divided into control group( n=36), IR group( n=30), PCOS alone group( n=28) and PCOS-IR group(PCOS with IR group, n=21). The concentrations of serum, follicular fluid LRG1 and SREBP1c levels in each group were compared, and their correlation with relevant hormones and glycolipid metabolism were analyzed. Results:The levels of serum, follicular fluid LRG1 and SREBP1c in IR group, PCOS alone group and PCOS-IR group were significantly higher than those in control group; The PCOS-IR group showed a more significant increase in the levels of serum, follicular fluid LRG1 and SREBP1c( P<0.05). Correlation analysis showed that serum, follicular fluid LRG1 was positively correlated with body mass index, fasting plasma glucose(FPG), fasting insulin(FINS), triglycerides(TG), and HOMA-IR( P<0.05). Serum, follicular fluid SREBP1c was positively correlated with body mass index, FPG, FINS, TG, total cholesterol, LDL-C, LH, total teststerone, DHEAS, FAI, and HOMA-IR( P<0.05). Binary logistic regression analysis showed that serum SREBP1c was a risk factor for PCOS( P<0.05). Conclusion:The serum and follicular fluid levels of LRG1 and SREBP-1c were elevated in PCOS patients, especially in those with IR. The elevated levels of serum and follicular fluid LRG1 and SREBP-1c may be associated with IR and glucose-lipid metabolism abnormalities in PCOS patients. Serum LRG1 and SREBP-1c levels may serve as new indicators for predicting IR, early diagnosis, and intervention in PCOS patients.
