Correlation between peripheral neuropathy and tumor markers in patients with type 2 diabetes mellitus
10.3760/cma.j.cn311282-20230121-00038
- VernacularTitle:2型糖尿病患者周围神经病变与血清肿瘤标志物的关系研究
- Author:
Lina CHEN
1
;
Qing SU
;
Hongmei ZHANG
Author Information
1. 上海交通大学医学院附属新华医院内分泌科 200092
- Keywords:
Diabetes mellitus, type 2;
Diabetic peripheral neuropathy;
Tumor markers
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(10):852-857
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between diabetic peripheral neuropathy(DPN)and the tumor markers in patients with type 2 diabetes(T2DM).Methods:A total of 956 patients with T2DM aged 40 to 70 years were hospitalized in the Department of Endocrinology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2018 to December 2020. There were 347 patients suffered from DPN and 609 patients were not. The differences of serum tumor markers between the two groups were analyzed. We explored the influencing factors independently related to DPN, determined the cutoff points of the tumor markers affecting DPN, and investigated the influencing factors of this tumor marker.Results:The levels of serum carcinoembryonic antigen(CEA), carbohydrate antigen(CA)125, and CA211 were significantly higher in T2DM patients with DPN than those without DPN(all P<0.05). CEA, CA211, age, HbA 1C, and diabetic duration were independent risk factors of DPN. The 2 h postprandial C-peptide was the independent protective factor of the DPN. We found the cutoff points of serum CEA and CA211 when the DPN happened were 2.915 ng/mL and 2.115 ng/mL. When the CEA and CA211 levels were above the cutoff points, the incidence risk of DPN was 1.803(95% CI 1.160-2.802)and 1.741(95% CI 1.150-2.635)times respectively, compared to below cutoff values. Conclusion:Serum CEA, CA125, and CA211 levels were significantly higher in T2DM patients with DPN than those without DPN. CEA and CA211 were independent risk factors of DPN and could potentially serve as markers for screening diabetic microvascular complications of diabetes mellitus.
