Dose-response relationship of remimazolam for loss of consciousness during anesthesia induction in patients undergoing coronary artery bypass grafting
10.3760/cma.j.cn131073.20230731.01118
- VernacularTitle:瑞马唑仑用于冠状动脉旁路移植术患者麻醉诱导时意识消失的量效关系
- Author:
Xiaodong XU
1
;
Ming JIN
;
Haoran ZHANG
;
Haitao SHAO
;
Jing CHENG
;
Hongqi LIN
;
Hongdang XU
Author Information
1. 河南省人民医院 郑州大学人民医院麻醉与围术期医学科，郑州 450000
- Keywords:
Benzodiazepines;
Coronary artery bypass, off-Pump;
Unconsciousness;
Dose-response relationship, drug
- From:
Chinese Journal of Anesthesiology
2023;43(11):1369-1372
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the dose-response relationship of remimazolam for loss of consciousness during anesthesia induction in the patients undergoing coronary artery bypass grafting (CABG).Methods:American Society of Anesthesiologists Physical Status classification Ⅲ or Ⅳpatients, aged 55-64 yr, with body mass index of 21-26 kg/m 2, scheduled for elective CABG under general anesthesia, were included in this study.The trial was conducted using the modified Dixon′s up-and-down method. The initial dose of remimazolam was 0.225 mg/kg, each time the concentration increased/decreased by 0.025 mg/kg in the next patient depending on whether or not the patients lost consciousness. Criteria for loss of consciousness was considered as the modified vigilance sedation score≤1 within 3 min after remimazolam administration. The 50% effective dose (ED 50), 95% effective dose (ED 95) and their 95% confidence interval ( CI) was analyzed by probit probability analysis method. Results:The ED 50 of remimazolam for loss of consciousness during anesthesia induction was 0.175 mg/kg, 95% CI was 0.163-0.185 mg/kg, ED 95 was 0.211 mg/kg, and 95% CI was 0.197-0.255 mg/kg. Conclusions:The ED 50 and ED 95 of remimazolam were 0.175 and 0.211 mg/kg respectively when used for loss of consciousness during anesthesia induction in the patients undergoing CABG.
