Research progress of tumor associated macrophages in bladder cancer immunotherapy
10.3760/cma.j.cn112330-20211205-00631
- VernacularTitle:肿瘤相关巨噬细胞在膀胱癌免疫治疗中的研究进展
- Author:
Weimin HU
1
;
Fan CHENG
;
Weimin YU
Author Information
1. 武汉大学人民医院泌尿外科，武汉 430060
- Keywords:
Urinary bladder neoplasms;
Carcinoma;
Cancer associated macrophages;
Immunotherapy;
Tumor microenvironment
- From:
Chinese Journal of Urology
2023;44(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Bladder cancer is one of the most common malignant tumors of the urinary system. Although immunotherapy has been applied to bladder cancer for many years, it still cannot achieve satisfactory results. Tumor associated macrophages play an important role in the immunosuppressive tumor microenvironment of bladder cancer, and affect the effect of BCG and ICIs immunotherapy on bladder cancer. Due to the high plasticity of TAM, different phenotypes of TAM have opposite effects in bladder cancer immunotherapy, while the complex interactions between TAM and other immune cells severely affect the efficacy of bladder cancer immunotherapy. Inhibition of monocyte recruitment to the tumor and TAM depletion, blockade of the M2 phenotype or reprogramming to the M1 phenotype, activation of TAM, and genetically engineered macrophages are new immunotherapeutic strategies targeting TAM in bladder cancer.
