Relationship between serum miR-665 and miR-144 levels and cardiac function in elderly patients with chronic heart failure
10.3969/j.issn.1009-0126.2024.02.011
- VernacularTitle:老年慢性心力衰竭患者血清微小RNA-665和微小RNA-144表达水平与心功能的关系
- Author:
Guimei LI
1
;
Hongmei ZHANG
;
Xiufeng XIE
Author Information
1. 010050 呼和浩特,内蒙古医科大学附属医院老年医学中心
- Keywords:
heart failure;
circulating microRNA;
echocardiography,Doppler,color;
correlation of data;
miR-665;
miR-144
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(2):163-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of miR-665 and miR-144 in the elderly pa-tients with chronic heart failure(CHF)and their relationship with cardiac function.Methods A total of 120 elderly CHF patients who were diagnosed and treated in our hospital from March 2021 to March 2023 were collected and then divided into NYHA grade Ⅱ(n=39),Ⅲ(n=51)and Ⅳ(n=30)subgroups according to the results of NYHA classification.Another 120 elderly healthy volunteers during the same period were recruited as the control group.Clinical data and cardiac function indicators were collected,and the expression levels of miR-665 and miR-144 in se-rum were detected.Pearson correlation analysis was applied to analyze the relationship of miR-665 and miR-144 levels with cardiac function indicators.Results The CHF group had significantly de-creased LVEF,increased left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD),and elevated serum levels of miR-665 and miR-144 than the control group(P＜0.01).Sequentially reduced LVEF and raised LVEDD and LVESD values and serum miR-665 and miR-144 levels were observed in the patients with NYHA grades Ⅱ,Ⅲ,and Ⅳ in turn(P＜0.01).Pearson correlation analysis showed that there was a positive correlation of the serum level of miR-665 with that of miR-144 in CHF patients(r=0.693,P=0.000),of the miR-665 and miR-144 levels with LVEDD(r=0.485,r=0.507,P＜0.01)and LVESD(r=0.539,r=0.494,P＜0.01),and a negative correlation of the serum levels with LVEF(r=-0.577,r=-0.591,P＜0.01).Conclusion The serum levels of miR-665 and miR-144 are elevated in elderly CHF patients,and are closely associated with their cardiac function.
