Value of serum exosomal circ_0023461 in diagnosis and prognosis of coronary artery disease related acute myocardial infarction
10.3969/j.issn.1009-0126.2023.10.010
- VernacularTitle:血清外泌体circ_0023461在冠状动脉疾病相关急性心肌梗死诊断和预后评估中的价值
- Author:
Guiqin ZANG
1
;
Dan YE
;
Yanyan SUN
Author Information
1. 100076 北京航天总医院急诊科
- Keywords:
coronary artery disease;
myocardial infarction;
exosomes;
diagnosis;
prognosis;
poly-merase chain reaction;
exosomal circ 0023461
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2023;25(10):1046-1050
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic and prognostic value of serum exosomal exocirc_0023461 in coronary artery disease(CAD)related acute myocardial infarction(AMI).Methods From December 2019 to January 2022,383 patients with CAD related AMI(AMI group),200 pa-tients with chronic stable CAD but no AMI(control group),and 200 healthy individuals identified with physical examination(healthy group)were recruited in our hospital.The serum exocirc_0023461 level was determined by real-time quantitative fluorescence polymerase chain reaction.The correlation of serum exosomal circ_0023461 level with clinicopathological features and oxida-tive stress indicators was analyzed.Results The serum level of exocirc_0023461 was significantly higher in the AMI group than the control group and healthy group[3.54(1.39,9.82)vs 0.86(0.62,1.23)and 0.65(0.41,0.79),P＜0.01].ROC curve analysis showed that when the serum level of exocirc_0023461 ≥1.31,its AUC value for the diagnosis of AMI was 0.857(95％CI:0.827-0.887),with a sensitivity and specificity of 78.90％and 83.50％,respectively.Kaplan-Meier survival curve displayed that the survival time was significantly shorter in the high level AMI patients without MACE than those with low level(X2=19.390,Plog rank＜0.01).Multivariate Cox regression analysis revealed that age,peripheral artery disease and serum exocirc_0023461 were independent predictors of MACE occurrence in AMI patients during follow-up(P＜0.05,P＜0.01).Pearson correlation analysis indicated that serum exocirc_0023461 level was negatively correlated with serum GPX and SOD levels(r=-0.395,r=-0.193,P＜0.01),and positively correlated with serum MDA level(r=0.194,P＜0.01).Conclusion Serum exocirc_0023461 may be a potential biomarker for the diagnosis and prognosis of CAD-related AMI,and its mechanism seems to be associated with its regulating oxidative stress and thus affecting myocardial injury.
