Research progress of relation between thyroid stimulating hormone and differentiated thyroid cancer

VernacularTitle:促甲状腺激素与分化型甲状腺癌关系的研究进展
Author: Liying HOU ¹ ; Guoqiang ZHANG ; Quanyong LUO
Author Information

1. 上海交通大学医学院附属第六人民医院核医学科，上海　200233
Keywords: Thyroid neoplasms; Thyrotropin; Trends
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2024;44(3):179-182
CountryChina
Language:Chinese
Abstract: Thyroid cancer is one of the most common tumors of the endocrine system, characterized by high morbidity and low mortality. Thyroid stimulating hormone (TSH) is an important factor in the development of thyroid cancer. TSH suppression therapy is widely used in clinical practice to reduce recurrence and metastasis through long-term strict monitoring and control of postoperative TSH level in patients with differentiated thyroid cancer (DTC). However, the specific mechanism of the effect played by TSH in the proliferation and progression of DTC has not been clarified. The current researches focus on classifying the relation between TSH and the onset risk, adverse clinicopathological factors and prognosis of DTC, and the applicable scope of TSH suppression therapy and targeted TSH receptor (TSHR) therapy. This article reviews the relation between TSH and DTC and the latest research progress of TSH suppression therapy and TSHR targeted therapy.