Research progress of autophagy in liver cancer
10.3760/cma.j.cn113884-20230521-00149
- VernacularTitle:自噬在肝癌中的研究进展
- Author:
Qingbo FENG
1
;
Xin ZHOU
;
Tao ZHANG
;
Weiwei NING
;
Zhengbiao LI
;
Ming XIE
Author Information
1. 遵义医科大学附属医院消化病医院 遵义医科大学附属医院普外科，遵义 563000
- Keywords:
Liver neoplasms;
Autophagy;
Tumor markers;
Targeted therapy
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(9):712-716
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a lysosomal dependent metabolic pathway that degrades cytoplasmic proteins and organelles via formation of autophagosomes to maintain homeostasis within the body. In recent years, with the continuous deepening of research and understanding on autophagy, it has been found that autophagy plays an important role in the occurrence of various tumor diseases and regulates autophagy could treat various tumors. Recent evidence suggests that autophagy plays a dual role in the occurrence of liver cancer: autophagy can clear damaged organelles and misfolded proteins, avoiding cell carcinogenesis; At the same time, it can also adapt malignant tumor cells to adverse environments such as chemotherapy drugs and hypoxia. This article aims to review the biological functions and molecular mechanisms of autophagy in liver cancer, and discussing the potential to modulate autophagy as a therapeutic strategy in the context of liver cancer.
