Recent advances in radiotherapy combined with systemic treatment for breast cancer brain metastasis
10.3760/cma.j.cn113030-20230209-00022
- VernacularTitle:乳腺癌脑转移放疗联合系统治疗研究进展
- Author:
Hu CHEN
1
;
Jing JIN
Author Information
1. 深圳大学医学部，深圳 518055
- Keywords:
Breast neoplasms;
Neoplasm metastasis, brain;
Radiation modalities;
Systemic therapy;
Combined treatment
- From:
Chinese Journal of Radiation Oncology
2024;33(2):178-183
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer brain metastasis (BCBM) is the second most common brain metastasis cancer, which is usually characterized by multiple lesions. Radiotherapy is an important local treatment for BCBM, which includes stereotactic radiotherapy, whole brain radiotherapy (WBRT) combined with simultaneous integrated boost and WBRT (such as conformal WBRT and hippocampal avoidance - WBRT) . Meanwhile, systemic treatment of BCBM has progressed rapidly, showing a positive effect in delaying the incidence of brain metastases, maintaining asymptomatic or unprogressive brain metastases, and delaying initial or salvage local treatments. In recent years, some studies have shown that radiotherapy combined with systemic treatment for BCBM has better application prospect compared with radiotherapy alone. In this article, the radiotherapy progress of brain metastases, the role of systemic therapy in BCBM, and the clinical research of radiotherapy combined with systemic therapy were reviewed, aiming to provide some reference for clinical research in this field.
