Research progress in the mechanism of elective nodal irradiation inhibiting anti-cancer immune response
10.3760/cma.j.cn113030-20221008-00332
- VernacularTitle:淋巴结预防性照射对机体免疫的影响
- Author:
Kuaile ZHAO
1
Author Information
1. 复旦大学附属肿瘤医院放射治疗中心，复旦大学上海医学院肿瘤学系，上海市放射肿瘤学重点实验室，上海市放射治疗临床医学研究中心，上海 200032
- Keywords:
Lymph nodes;
Elective nodal irradiation;
Immunity;
Neoplasms
- From:
Chinese Journal of Radiation Oncology
2023;32(10):875-880
- CountryChina
- Language:Chinese
-
Abstract:
In the era of immunotherapy, the advantages and limitations brought from elective nodal irradiation (ENI) needs to be re-evaluated. As immune organs, lymph nodes play a crucial role as barriers against cancer, and are involved in the activation of anti-tumor responses during radiotherapy. Numerous animal experiments have demonstrated a significant depletion of cytotoxic T cells in the tumor microenvironment, along with an increase in radiation resistance after ENI or surgical resection, leading to limited tumor regression. Furthermore, the abscopal effect stimulated by radiotherapy is markedly attenuated when ENI is combined with immunotherapy. In this article, research progress in the underlying mechanisms was reviewed.
