A review of regulatory effects of radiation on the polarization and functions of macrophages
10.3760/cma.j.cn112271-20230207-00028
- VernacularTitle:辐射对巨噬细胞极化和功能的调节作用
- Author:
Weiguo LI
1
;
Gang GAO
;
Yan PAN
;
Jianlei RUAN
;
Jianxiang LIU
Author Information
1. 中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室，北京 100088
- Keywords:
Macrophage;
Polarization;
Radiation;
Signaling pathway
- From:
Chinese Journal of Radiological Medicine and Protection
2023;43(10):839-844
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages, as regulatory cells existing in all tissues, exhibit complex responses to radiation stimulation, including both common processes in response to infection and injury and unique polarization transformation. Radiation-related polarization determines the functional types of macrophages. After being exposed to different irradiations, macrophages are regulated by different cytokines, involving multiple signaling pathways. This leads to differential degrees of polarization. The review summarized the regulatory effects of radiation on the polarization and functions of macrophages in order to provide basis for theoretical research on immunity and clinical radiotherapy.
