Imaging findings and related risk factors of small vessel cerebral vascular disease in patients with systemic lupus erythematosus
10.3760/cma.j.cn141217-20221119-00473
- VernacularTitle:系统性红斑狼疮患者脑小血管病影像学表现及其相关危险因素研究
- Author:
Yue MA
1
;
Ning TIE
;
Pengfei QIAO
;
Sha NI
;
Xueying MA
Author Information
1. 内蒙古医科大学第一临床医学院，呼和浩特 010050
- Keywords:
Lupus erythematosus, systemic;
Cerebral small vascular disease;
Risk factors;
White ma-tter hyperintense
- From:
Chinese Journal of Rheumatology
2023;27(9):611-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics of imaging findings and related risk factors of small vessel cerebral vascular disease (CSVD) in patients with systemic lupus erythematosus (SLE) with different disease activity.Methods:One hundred and ninty four SLE patients were included. Patients were divided into three groups according to systemic lupus erythematosus disease activity index (SLEDAI): stable or mild active disease group (0~9 points) ( n=107), moderate active group (10~14 points) ( n=41), severe active group (≥ 15 points) ( n=46). Imaging findings, general clinical information laboratory tests of all patients were collected, and the imaging data were scored according to the small cerebral vessel score scale. CSVD-related risk factors of SLE patients in the three groups were analyzed by using ordered Logistic regression. Results:There were significant differences in TWMH score, TPVS score and CSVD score among the three groups ( H=6.07, 6.00, 9.63, P<0.05). Orderly logistic regression showed that age [ OR(95% CI)=1.119 (1.051, 1.891), P<0.001], HCT [ OR (95% CI)=1.531 (1.158, 2.026), P=0.003], anti-PM-Scl antibody [ OR (95% CI)=17.271 (1.442, 206.851), P=0.025] were risk factors for CSVD in the severe active disease group. RBC [ OR(95% CI)=0.011 (0.001, 0.155), P=0.001]、anti-Rib.p antibody [ OR(95% CI)=0.093 (0.018,0.047), P=0.004] were protective factors for CSVD. Conclusion:The manifestations of CSVD in SLE patients with different disease activity are different, and are affected by age, part of blood indicators and lupus antibodies.
