Molecular mechanism of cognitive dysfunction caused by blast traumatic brain injury: a review
10.3760/cma.j.cn501098-20230825-00109
- VernacularTitle:颅脑爆震伤致认知功能障碍的分子机制研究进展
- Author:
Liang LI
1
;
Qi WANG
;
Xiaolin FAN
;
Hong WANG
;
Xiao LI
;
Boya YU
;
Junhong GAO
Author Information
1. 兵器工业卫生研究所，西安市毒理与生物效应重点实验室，西安 710065
- Keywords:
Craniocerebral trauma;
Blast injuries;
Cognition disorders;
Molecular mechanism
- From:
Chinese Journal of Trauma
2024;40(1):87-92
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive dysfunction caused by blast traumatic brain injury (bTBI) is a serious neurological disease with high incidence, serious condition and poor prognosis. bTBI can lead to a series of symptoms such as short-term memory loss, inattention or multi-tasking difficulties. In severe cases, bTBI can develop into Alzheimer′s disease, which has a great impact on patients′ normal work and life. At present, researches on cognitive dysfunction caused by bTBI mainly involve model construction, pathogenesis, pathophysiological changes, diagnosis and treatment, etc., and the molecular mechanism of its occurrence remains to be further studied. Under normal physiological conditions, the release of excitatory and inhibitory neurotransmitters, the release and uptake of Ca 2+, oxidation and antioxidant systems, and the promotion and inhibition of apoptosis are in a dynamic balance. bTBI disturbs the balance, which will lead to the damage of nerve cells at the molecular level, thus resulting in the occurrence of cognitive dysfunction. To this end, the authors summarized the aspects of excitatory toxicity and Ca 2+homeostasis disorder, oxidative stress, inflammation and edema, apoptosis, etc., and reviewed the research progress on the molecular mechanism of cognitive dysfunction caused by bTBI, so as to provide a reference for the treatment and rehabilitation of cognitive dysfunction in patients with bTBI.
