Construction of vascularized organoid-on-a-chip: a review
10.3760/cma.j.cn501098-20230731-00055
- VernacularTitle:血管化类器官芯片构建的研究进展
- Author:
Zhangjie LI
1
;
Chenyang ZHOU
;
Xiaolin WANG
Author Information
1. 上海交通大学电子信息与电气工程学院微纳电子学系，上海 200240
- Keywords:
Organoids;
Neovascularization, physiological;
Multipotent stem cells;
Microfluidic chips
- From:
Chinese Journal of Trauma
2024;40(1):48-56
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, advancements in microfabrication technology and tissue engineering have propelled the development of a novel platform known as organoid-on-a-chip for drug screening and disease modeling. This platform integrates organoids and organ-on-a-chip technologies, emerging as a promising approach for in vitro modeling of human organs. Organ-on-a-chip leverages microfluidic device to simulate the physiological environment of specific organs, offering a more dynamic and flexible setting that can mimic a more comprehensive human biological context. However, the lack of functional vasculature has remained a major challenge in this technology. Vascularization is crucial for the long-term cultivation and in vitro modeling of organoids, which is of great significance in drug development and personalized medical approaches. The authors reviewed the research progress in the construction of vascularized organoid-on-a-chip including the methods for constructing in vitro vascularized models, vascularization of organoids, etc, which may serve as a reference for the construction of fully functional vascularized organoid-on-a-chip.
