Research progress on"one-two punch"strategy in the therapy of glioma
10.12354/j.issn.1000-8179.2023.20230933
- VernacularTitle:在胶质瘤治疗中应用"组合拳式"策略的研究
- Author:
Kui ZHANG
1
;
Kai ZHAO
;
Wenhu LI
;
Minhao HUANG
;
Ninghui ZHAO
Author Information
1. 昆明医科大学第二附属医院神经外科 昆明市 650000
- Keywords:
"one-two punch"strategy;
cellular senescence;
senolytic;
glioblastoma(GBM)
- From:
Chinese Journal of Clinical Oncology
2023;50(21):1106-1109
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma(GBM)originates from glial cells,and complete surgical resection followed by radiotherapy and chemotherapy is the current standard treatment.However,gliomas are subjected to not only accelerated cell death after radiotherapy and chemotherapy but also cellular senescence.Senescent cells produce a senescence-associated secretory phenotype(SASP),which has a dual effect on the tumor microenvironment.The"one-two punch"strategy of specifically eliminating senescent cells and inhibiting SASP-derived secretions provides a new direction for tumor therapy.In this article,we review the mechanisms that mediate tumor cellular senescence and SASP,the elimina-tion of senescent cells by senolytics for SASP inhibition,and the current situation of the"one-two punch"strategy for the treatment of glioma.
