The effect of different doses of butorphanol tartrate prophylactic analgesia on postoperative pain in gynecological laparoscopic surgery
10.3760/cma.j.cn431274-20231007-00346
- VernacularTitle:不同剂量酒石酸布托啡诺预防性镇痛对妇科腹腔镜手术术后疼痛的影响
- Author:
Mingjie ZHANG
1
;
Zhongliang SUN
;
Defeng SUN
Author Information
1. 大连医科大学附属第一医院麻醉科，大连 116011
- Keywords:
Gynecologic surgical procedures;
Laparoscopy;
Pain, postoperative;
Butorphanol;
Analgesia
- From:
Journal of Chinese Physician
2023;25(11):1630-1634
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of pre injection of three different doses of butorphanol tartrate on postoperative pain in gynecological laparoscopic surgery.Methods:A prospective study was conducted on 172 patients who underwent gynecological laparoscopic surgery under general anesthesia at the First Affiliated Hospital of Dalian Medical University from April to December 2022. According to the random number table method, patients were divided into B1 group, B2 group, and B3 group. These three groups were given 10, 20, and 30 μ g/kg butorphanol tartrate 15 minutes before surgery, respectively. Ramsay sedation score at 10 minutes after patient administration, the pain Numerical Rating Scale (NRS) scores and Bruggrmann Comfort Scale (BCS) for resting and active states at 2, 6, 12, 24, and 48 hours after surgery, hemodynamic parameters at different time points during surgery, postoperative use of adjuvant analgesics and effective number of compressions for patient-controlled intravenous analgesia (PCIA) and the incidence of postoperative adverse reactions were recorded.Resultsl:There was no statistically significant difference in general characteristics among the three groups of patients (all P>0.05). At 10 minutes after administration, there was a statistically significant difference in Ramsay scores between groups B2 and B3 compared to group B1 (all P<0.05). At 12 and 24 hours after surgery, the resting NRS score of B3 group was lower than that of B2 group and B1 group, and B2 group was lower than B1 group (all P<0.05); At 6, 12, and 24 hours after surgery, the NRS scores of postoperative activity in the B2 and B3 groups were lower than those in the B1 group (all P<0.05); At 6 and 12 hours after surgery, the NRS score of the B3 group was lower than that of the B2 group (all P<0.05). At 6 and 24 hours after surgery, there was a statistically significant difference in BCS between groups B2 and B3 compared to group B1 (all P<0.05). There was no statistically significant difference in the hemodynamic parameters at each time point during surgery, the effective number of PCIA compressions within 48 hours after surgery, and the incidence of postoperative adverse reactions among the three groups of patients (all P>0.05). There was a statistically significant difference in the rate of postoperative addition of analgesics among the three groups ( P<0.05). Conclusions:Intravenous injection of 15 minutes before gynecological laparoscopic surgery 30 μg/kg butorphanol tartrate can achieve good analgesic effects with fewer adverse reactions, and can be used as a priority dose for preventive analgesia in gynecological laparoscopic surgery.
