Electrophysiological analysis of early warning information processing in children with transient tic disorder
10.3760/cma.j.cn371468-20230404-00155
- VernacularTitle:短暂性抽动障碍儿童预警信息加工过程的电生理分析
- Author:
Lina LIAO
1
;
Ting WU
;
Jianrong LIU
;
Yang YI
;
Chaoqun WANG
;
Xiaoping JIANG
Author Information
1. 南通大学附属常州儿童医院神经内科，常州 213000
- Keywords:
Transient tic disorder;
Event related potential, N2;
Event related potential, P3b;
Event related potential CNV;
Early warning information processing;
Child
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(12):1099-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changing characteristics of early warning information ability in children with transient tic disorder(TTD).Methods:A total of 32 children with TTD(TTD group) diagnosed and treated at Changzhou Children's Hospital from 2018 to 2022 and 36 healthy control children(HC group) recruited from ordinary primary schools in Changzhou city were tested with CPT-Go/Nogo task and their behavioral data and cue/uncue-N2, P3b and CNV components of event related potential(ERP) were analyzed and compared by SPSS 25.0 software.Results:(1)Comparison of behavioral data: there was no statistical difference in the correct number(37(34, 39) vs 38(37, 40)), false number(1(0, 2) vs 1(0, 2))and correct reaction time((511.27±99.27)ms vs(504.88±92.23)ms)between TTD and HC group(all P>0.05). (2) Comparison of ERP components: in the HC group, the amplitudes of cue-CNV were higher than those in uncue-CNV in lead Cz((-4.61±4.67)μV vs(-1.07±3.20)μV)and Pz((-4.17±3.74)μV vs(-1.79±3.49)μV) and the differences were statistically significant(both P<0.01). The amplitude of cue-P3b in lead Pz were higher than that in uncue-P3b((9.13±4.99)μV vs(6.12±6.24)μV) and the difference was statistically significant( P<0.01). Compare with HC group((-4.12±4.25)μV, (-4.61±4.67)μV, (9.13±4.99)μV), the amplitudes of uncue-N2, cue-CNV and cue-P3b in TTD group((-1.29±4.48)μV, (-2.03±3.19)μV, (6.59±3.41)μV) were respectively lower, and the differences were statistically significant(all P<0.05). Conclusion:Children with TTD may have dysfunction in conflict monitoring, attention allocation, and maintaining alertness when processing early warning information, but there may be corresponding compensation mechanisms for brain function.
