Advances in NLRP3-mediated neuroinflammation in Parkinson disease
10.3760/cma.j.cn371468-20221214-00753
- VernacularTitle:NLRP3介导神经炎性反应在帕金森病中的研究进展
- Author:
Yan GUO
1
;
Baohua CHENG
;
Haiyan YIN
Author Information
1. 济宁医学院基础医学院组织学与胚胎学教研室，济宁 262067
- Keywords:
Parkinson disease;
NLRP3 inflammasome;
Microglia;
α-synuclein;
Mitochondria
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(9):859-864
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson disease (PD) is a neurodegenerative disorder characterized by striatal dopamine deficiency due to degenerative death of midbrain nigrostriatal dopaminergic neurons and the presence of intracellular α-synuclein aggregates.The inflammation caused by NLRP3 inflammasome mediated by microglia overactivation in the midbrain substantia nigra promotes the degeneration of dopamine neurons and plays a key role in the development of PD.α-synuclein aggregation, mitochondrial dysfunction, autophagy and dopamine receptor defects are key regulators of the degeneration of substantia nigra neurons mediated by microglia NLRP3 inflammasome activation.In this paper, we summarize the role of molecular mechanisms of microglia NLRP3 inflammasome activation and regulation in PD, and discuss the main potential PD therapeutic targets or approaches targeting NLRP3 inflammasome mechanisms, with the aim of providing the theoretical basis and insight for PD treatment.
