Research progress on the pathogenesis and treatment of gallbladder cancer
10.3969/j.issn.1009-9905.2024.02.001
- VernacularTitle:胆囊癌发病机制及治疗的研究进展
- Author:
Jian-Qiang CAO
1
;
Sheng-Biao YANG
;
Xi-Qiang WANG
;
Hui-Jie GAO
;
Zhao-Bin HE
;
Cheng PENG
;
Jun NIU
Author Information
1. 山东大学齐鲁医院 肝胆外科(山东 济南 250012);山东大学腔镜微创外科研究所(山东 济南 250012)
- Keywords:
Gallbladder Cancer;
Pathogenesis;
Treatment
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(2):85-91
- CountryChina
- Language:Chinese
-
Abstract:
Gallbladder carcinoma,a relatively rare malignancy within the biliary tract,presents a grave prognosis primarily due to asymptomatic early stages leading to advanced stage diagnosis and the absence of efficacious treatment options.Research has identified chronic inflammation,predom-inantly caused by gallstones,as a critical etiological factor.While surgical intervention offers potential curative outcomes in early stages,the majority of cases are identified too late for optimal surgical outcomes.Chemotherapy and targeted therapy,despite offering new therapeutic avenues,have not significantly improved overall survival rates.Thus,understanding the pathogenesis of gallbladder cancer,especially its association with key genetic and molecular pathways,is imperative for devising novel therapeutic strategies.This review delineates the epidemiology,pathogenesis,current treat-ment modalities,and research advancements in gallbladder cancer,aiming to provide innovative in-sights for clinical management and guide future research endeavors.
