Exploration of the significance of NOX4 in the evaluation of gastric cancer
10.3969/j.issn.1009-9905.2024.01.008
- VernacularTitle:NOX4在胃癌评价中的意义探索
- Author:
Jian-Yi ZHAO
1
;
Meng-Meng CHEN
;
Xiao LIU
;
Yin-Zhong WANG
Author Information
1. 焦作市第二人民医院普外一区(河南 焦作 454001)
- Keywords:
Stomach neoplasms;
NOX4;
Signal pathway;
Immune cell infiltration
- From:
Chinese Journal of Current Advances in General Surgery
2024;27(1):36-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This article is to investigate NADPH oxidase 4(NOX4)expression,prog-nosis,signaling pathway and key immune cells infiltrating in tumor tissues in gastric cancer.Meth-ods:Data were downloaded from the Cancer Genome Atlas(TCGA)and the Integrated Gene Ex-pression Database(GEO).The expression of NOX4 in gastric cancer and normal tissues,the rela-tionship between NOX4 expression level and clinical characteristics of patients,gene enrichment analysis of signaling pathways and immune infiltration analysis have been analyzed.Results:In terms of NOX4 expression,tumor tissue is significantly higher than normal tissue,which has certain diagnostic value;NOX4 is an important prognostic factor with poor prognosis in patients with high NOX4 expression;NOX4 is associated with cell adhesion molecules(CAMs),transforming growth factor-β(TGF-β),and WNT signaling pathway.NOX4 high expression group was mainly related to M2 macrophages and plasma cell infiltration in tumor tissues.Conclusion:NOX4 plays an impor-tant role in the progression of gastric cancer(GC).
