Clinical effects of hypoglycemic drugs in patients with type 2 diabetes mellitus and depression
10.3969/j.issn.1006-6187.2024.03.007
- VernacularTitle:降糖药物治疗2型糖尿病伴抑郁患者的效果观察
- Author:
Hao YUAN
1
;
Chuyu ZHONG
;
Qiong WU
;
Li WANG
;
Qianqian WANG
;
Lie FENG
Author Information
1. 519000 珠海市第三人民医院内分泌代谢科
- Keywords:
Diabetes mellitus,type 2;
Hypoglycemic drugs;
Depression degree
- From:
Chinese Journal of Diabetes
2024;32(3):192-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effects of hypoglycemic drugs on depression degree in patients with type 2 diabetes mellitus(T2DM).Methods A total of 160 newly diagnosed T2DM patients or T2DM patients who have not used hypoglycemic drugs in the past 3 months with mild to moderate depressive episodes and visited our outpatient department were enrolled in this study from January to December 2022.All the participants HbA1c were ranged from 7%to 9%.They were randomly divided into four groups:Metformin treatment group(Met,n=40),Met combined with sulfonylurea treatment group(Met+SUs,n=40),Met combined with DPP-4i treatment group(Met+DPP-4i,n=40),and Met combined with GLP-1 receptor agonist treatment group(Met+GLP-1RA,n=40).All the patients were scored with the Hamilton Depression Rating Scale(HAMD)and the Hamilton Anxiety Rating Scale(HAMA)in each group.Results The Met+DPP-4i and Met+GLP-1RA groups showed the most significant decrease in HAMD and HAMA scores after treatment(P<0.05),while the proportion of moderate depression and significant anxiety in HAMD decreased(P<0.05).Pearson correlation analysis showed that?HAMD,?HAMA were positively correlated with ?HbA1c in the Met+GLP-1RA group(P<0.05).Conclusion The combination of Met with DPP-4i and GLP-1RA has the most significant effect on improving the degree of depression in patients with T2DM and depression.
