Correlation between glycated hemoglobin index and insulin antibody positive in type 2 diabetes mellitus patients with poor oral hypoglycemic control
10.3969/j.issn.1006-6187.2024.03.005
- VernacularTitle:口服降糖药控制不佳的2型糖尿病患者糖化血红蛋白指数与胰岛素抗体阳性相关性的研究
- Author:
Yan WU
1
;
Xiang WU
Author Information
1. 570203 海口市骨科与糖尿病医院检验科
- Keywords:
Diabetes mellitus,type 2;
Glycated hemoglobin index;
Insulin autoantibody;
Insulin resistance
- From:
Chinese Journal of Diabetes
2024;32(3):182-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between glycated hemoglobin index(HGI)and insulin antibody(IAA)positivity in type 2 diabetes mellitus(T2DM)patients with poorly controlled oral hypoglycemic agents.Methods A total of 260 T2DM patients with poor control of oral hypoglycemic agents and receiving insulin treatment in the Department of Endocrinology of Orthopedics and Diabetes Hospital of Haikou City from January 2020 to December 2021 were selected and divided into IAA positive group(n=75)and IAA negative group(n=185).Clinical data and biochemical indicators of the two groups were compared and analyzed the correlation between IAA positivity and other indicators.Results IAA positive group had a higher proportion of patients with insulin high dosage,insulin treatment time>2 years,and higher FIns,FPG,SUA and HGI than IAA negative group(P<0.05 or P<0.01),HbA1c≥9%lower than IAA negative group(P<0.01).Spearman correlation analysis showed that IAA positive was positively correlated with HGI(P<0.01),and negatively correlated with SUA and HDL-C(P<0.01).Logistic regression analysis showed that insulin treatment time,FIns,FPG,SUA,HbA1c and HGI were the influencing factors for IAA positive in T2DM patients.Receiver operating characteristic curve analysis showed that the area under the ROC curve for predicting IAA positive by HGI was 0.854,the optimal critical value for HGI was 0.4%,with the sensitivity 83.2%and the specificity 79.3%.Conclusion In T2DM patients with poorly controlled oral hypoglycemic drugs,high HGI has predictive value for IAA positivity.
