Abnormal blood transfusion compatibility test results caused by delayed hemolytic reaction: a case report and transfusion strategy
10.13303/j.cjbt.issn.1004549x.2024.03.015
- VernacularTitle:迟发性溶血反应致输血相容性检测结果异常与输血策略
- Author:
Fang QIU
1
;
Fengqing ZHANG
2
;
Ying ZHU
1
Author Information
1. Department of Blood Transfusion, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China
2. Gannan Medical University
- Publication Type:Journal Article
- Keywords:
blood transfusion compatibility testing;
delayed hemolytic reaction;
thalassemia
- From:
Chinese Journal of Blood Transfusion
2024;37(3):348-351
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the blood transfusion compatibility test results of a child with thalassemia after delayed hemolysis reaction, and to formulate transfusion strategies based on other clinical data to ensure the safety of clinical blood use. 【Methods】 A comprehensive analysis was conducted on the transfusion compatibility test results of a child with thalassemia, combined with Rh blood type system detection, blood transfusion history, serum bilirubin changes, clinical symptoms and other data to determine the occurrence of delayed hemolytic reaction, and formulate the subsequent appropriate blood matching strategies. 【Results】 On admission, the blood type of the patient was B DccEE, with hemoglobin (Hb) 38 g/L, reticulocyte ratio (Ret%) 2.92%, total bilirubin (TBil) 65.8 μmol/L, direct bilirubin (DBil) 12.0 μmol/L, indirect Bilirubin (IBil) 53.8 μmol/L, negative for unexpected antibody screening, no agglutination or hemolysis on both primary and secondary sides of the cross-matching over with type B DCcEe donors, negative for direct anti human globulin test(DAT), negative for indirect anti human globulin test (IAT), lactate dehydrogenase(LDH) 1 050 U/L, aspartate aminotransferase(AST) 113 U/L, urine occult blood 2+, urine bilinogen 4+, and a history of red blood cell transfusion 5 days before admission. The above results indicated that the child had a delayed hemolytic reaction, then type B DccEE leukocyte-depleted suspension red blood cell was transfused, and various indicators improved after transfusion. 【Conclusion】 Appropriate blood matching strategies should be formulated based on the results of blood transfusion compatibility testing and other clinical data before transfusion for children with thalassemia in order to effectively ensure transfusion safety.
