Research progress in the colistin resistance gene mcr-1
10.3969/j.issn.1002-2694.2023.00.138
- VernacularTitle:黏菌素耐药基因mcr-1的研究进展
- Author:
Qi-Qi ZHU
1
;
Ning-Ning LU
;
Cheng-Ye WANG
;
Ling-Yu WU
;
Ji-Yu ZHANG
;
Zhen ZHU
;
Wei-Wei WANG
Author Information
1. 中国农业科学院兰州畜牧与兽药研究所,兰州 730050;河北工程大学生命科学与食品工程学院,邯郸 056000
- Keywords:
colistin;
mcr-1;
epidemic situation;
resistance mechanism;
transmission mechanism
- From:
Chinese Journal of Zoonoses
2023;39(12):1211-1217
- CountryChina
- Language:Chinese
-
Abstract:
Polymyxin antibiotics,particularly polymyxin B and polymyxin E(colistin),are often considered a last line of defense against penicillin carbapenem-resistant Enterobacteriaceae(CRE),because of their favorable clinical antibacterial effects.However,the emergence and spread of plasmid-mediated colistin resistance genes(mcr),and their multiple isoforms,have posed a substantial threat to public health in recent years.The mcr-1 genes exhibit complexity in both host and transmis-sion routes,and diversity in both the genetic environment and ecological locus distribution.Herein,we discuss the prevalence,transmission routes,drug resistance and transmission mechanisms of mcr-1 positive isolates,on the basis of epidemiological studies of Enterobacteriaceae carrying mcr-1 worldwide.to provide a theoretical reference for researchers.
