Application of nanobodies in autoimmune diseases
10.3969/j.issn.1000-484X.2024.01.028
- VernacularTitle:纳米抗体在自身免疫性疾病中的应用
- Author:
Zhenghong AO
1
;
Yue WANG
;
Yaxian MEI
;
Wenxin LUO
Author Information
1. 厦门大学公共卫生学院,国家传染病诊断试剂与疫苗工程技术研究中心,厦门 361102
- Keywords:
Nanobody;
Autoimmune diseases;
Cytokines
- From:
Chinese Journal of Immunology
2024;40(1):178-184
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune disease is a kind of heterogeneous disease caused by the loss of immune tolerance to autoantigens.In recent years,antibody drug has become an important choice for the treatment of autoimmune diseases.Monoclonal antibodies are limited by their large relative molecular mass and difficult to penetrate solid tissues,while nanobodies,the smallest antibody fragment known to date with intact antigen recognition,have gained much attention in the treatment of autoimmune diseases due to their ease of modifi-cation,high penetration,and ability to target more cryptic epitopes.The review focuses on the application of nanobodies in the treat-ment of diseases such as rheumatoid arthritis,acquired thrombotic thrombocytopenic purpura,systemic lupus erythematosus,psoria-sis,and looks forward to the prospect of nanobodies in the treatment of autoimmune diseases.
