Progress in study of biomarkers for predicting efficacy of sublingual immunotherapy for allergic rhinitis

VernacularTitle:舌下免疫治疗变应性鼻炎疗效预测生物标志物研究进展
Author: Qi ZOU ¹ ; Qi SHEN ; Xiangdong GUO
Author Information

1. 河南中医药大学,郑州 450000
Keywords: Immunotherapy; Rhinitis,allergic; Biomarkers
From: Chinese Journal of Immunology 2023;39(12):2672-2678
CountryChina
Language:Chinese
Abstract: Allergic rhinitis(AR)is a typeⅠallergy of the nasal mucosa mediated by IgE.Allergen specific immunotherapy(AIT)can not only control nasal symptoms effectively and long term,but also change the natural course of disease.Due to the poor re-sponse of some patients to allergen specific immunotherapy and the long course of treatment,it is critical to identify biological indica-tors that can predict and evaluate the efficacy.This review reviews the progress in the study of biomarkers for the prediction and evalua-tion of the efficacy of sublingual immunotherapy(SLIT)for AR.The changes of various immune cells,immunoglobulin and cytokines are related to the efficacy of SLIT and are considered as candidate biomarkers,but their effectiveness and relevance remain to be fur-ther verified.