Effects of food for specific medical purposes on muscle status, exercise capacity and nutrient metabolism in patients at nutritional risk
10.3760/cma.j.cn115822-20230607-00092
- VernacularTitle:全营养配方特殊医学用途配方食品对有营养风险患者肌肉状况、运动能力及营养代谢的影响
- Author:
Jin FU
1
;
Kang YU
;
Yu ZHANG
;
Yuanyuan BAO
;
Shanshan LI
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院临床营养科 100730
- Keywords:
Nutritional risk;
Nutritional intervention;
Foods for special medical purposes;
Double-blind randomized controlled study
- From:
Chinese Journal of Clinical Nutrition
2023;31(5):257-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of foods for special medical purposes (FSMP) on physical performance, body composition, nutritional metabolic indicator levels, and inflammatory factor levels in patients at nutritional risk.Methods:A single-center, double-blind, randomized, controlled clinical study was conducted. Patients at nutritional risk were randomized to two groups. Both groups received the nutritional management for 8 weeks, including 30 gram of nutritional preparations thrice a day, standard meals, and nutritional education. The intervention group was given full nutritional FSMP while the control group was given isocaloric placebo. The primary outcomes were the changes in timed up and go (TUG) test score, grip strength and muscle mass measured by bioelectrical impedance analysis after the intervention. The secondary outcomes were the walking speed as measured by 4-meter walk test, calf circumference, blood 25 hydroxyvitamin D 3 (25-OH-VD 3), and high-sensitivity C-reactive protein. Other indicators examined included serum albumin and prealbumin and inflammatory factors, and T cell and B cell subsets. Results:Forty-five patients were enrolled and 25 completed the intervention and follow-up period. There were no significant differences between groups in sex, age, height, and weight. Muscle mass ( P=0.042), upper limb muscle mass ( P=0.035), and grip strength ( P=0.032) were significantly increased in the intervention group compared to the control group, while TUG score was significantly reduced ( P=0.047). Four-meter walk test time, calf circumference, inflammatory indicators, and serum indicators did not change significantly after the intervention( P>0.05). TUG score was positively correlated with 4-meter walk time, interleukin-8, while negatively correlated with grip strength, 25-OH-VD 3 and serum albumin. Conclusions:The full nutritional FSMP was safe and effective for long term use in patients at nutritional risk, improving physical performance and muscle mass. However, no significant effect of full nutritional FSMP were observed on serum nutritional indicators and inflammatory factors.
