Research progress of the effect of TMAO on coronary heart disease and the efficacy of antiplatelet drugs
10.12092/j.issn.1009-2501.2024.05.015
- VernacularTitle:氧化三甲胺影响冠心病和抗血小板药物疗效的研究进展
- Author:
Yuanyuan PENG
1
;
Bilian CHEN
Author Information
1. 中南大学湘雅医院老年医学科,长沙 410078,湖南
- Keywords:
trimethylamine N-oxide;
coronary heart disease;
antiplatelet drug
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(5):590-595
- CountryChina
- Language:Chinese
-
Abstract:
Coronary heart disease is still one of the most common cardiovascular disease and causes of death worldwide(including China).Anti-platelet drugs are fundamental in the treatment of coronary heart disease.In recent years,more and more studies have found that trimethylamine N-ox-ide(TMAO),a major metabolite of intestinal flora,can promote atherosclerosis through various mech-anisms,affecting the prognosis of patients with cor-onary heart disease and the efficacy of antiplatelet drugs.This article reviews the effect of TMAO on coronary heart disease and the efficacy of anti-platelet drugs.
