Effect of thymalfasin combined with ganciclovir eye drops (gel) on herpes simplex virus epithelial keratitis
10.3760/cma.j.cn341190-20231019-00316
- VernacularTitle:胸腺法新联合更昔洛韦滴眼液（凝胶）治疗单纯疱疹病毒性上皮型角膜炎的效果观察
- Author:
Huiping DUAN
1
Author Information
1. 山西省汾阳医院眼科，汾阳 032200
- Keywords:
Keratitis, herpetic;
Treatment outcome;
Recurrence;
Immunity, cellular;
Immunity, humoral;
Thymalfasin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(4):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of thymalfasin combined with ganciclovir eye drops (gel) in the treatment of herpes simplex virus epithelial keratitis.Methods:This study enrolled 80 patients with herpes simplex virus epithelial keratitis who were treated at the Department of Ophthalmology, Fenyang Hospital, between January 2019 and December 2020. These patients were randomly divided into a control group and an observation group, with 40 patients in each group using the random number table method. All patients were treated with ganciclovir eye drops (gel) for 3 weeks. The control group received conventional treatment, while the observation group received both conventional treatment and thymalfasin treatment. All patients were followed up for 2 years. The proportion of patients who achieved a significant response and an effective response within 10 days of treatment, as well as the recurrence rate, were compared between the two groups. Additionally, the changes in cellular immune function were compared between the two groups.Results:In the control group, there were 10 cases that achieved a significant or effective response within 10 days of treatment, while in the observation group, there were 28 cases. The therapeutic effect of the observation group was superior to that of the control group, and the difference was statistically significant ( χ2 = 16.24, P < 0.001). The recurrence rate of the observation group within 2 years was significantly lower than that of the control group (10.00% vs. 30.00%, χ2 = 5.00, P < 0.05). After treatment, the counts of CD3 +, CD4 +, CD4 +/CD8 +, and natural killer cells, which are indices of cellular immune function, were significantly increased in the observation group compared with both their pre-treatment levels and the levels measured concurrently in the control group ( tbetween-group= 19.27, 20.85, 11.32, 15.82, all P < 0.001). Conclusion:The combination of thymalfasin and ganciclovir eye drops (gel) for the treatment of herpes simplex virus epithelial keratitis can improve both the therapeutic effect and the immune function of patients, which helps to reduce the recurrence rate.
