The combined value of fine needle aspiration cytology and BRAF V600E gene mutation detection in the diagnosis of thyroid nodules
10.3760/cma.j.cn341190-20230907-00170
- VernacularTitle:细针抽吸细胞学联合检测BRAF V600E在甲状腺结节诊断中的应用价值
- Author:
Xiaoping HUANG
1
;
Jun HE
Author Information
1. 温州市中心医院病理科，温州 325000
- Keywords:
Thyroid nodule;
Carcinoma, papillary;
Pathology;
Suction;
Cytological techniques;
Sensitivity and specificity;
Protein-serine-threonine kinases
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(3):342-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of the combined use of fine needle aspiration cytology (FNAC) and BRAF V600E gene mutation detection in the preoperative diagnosis of thyroid nodules. Methods:A retrospective analysis was conducted on 126 cases of thyroid nodules confirmed by routine histopathology after surgery at Wenzhou Central Hospital between January 2022 and January 2023. The results of preoperative FNAC combined with BRAF V600E gene mutation detection were compared with those obtained from FNAC alone. Results:There was no significant difference in specificity for thyroid nodules between FNAC combined with BRAF V600E gene mutation detection and FNAC alone ( P > 0.05). The sensitivity of FNAC combined with BRAF V600E gene mutation detection was significantly higher than that of FNAC alone [97.6% (82/84) vs. 85.5% (65/76), χ2 = 7.82, P < 0.05]. The overall accuracy of FNAC combined with BRAF V600E gene mutation detection was significantly higher than that of FNAC alone [96.8% (122/126) vs. 85.0% (96/113), χ2 = 10.47, P < 0.05]. Conclusion:The combined application of FNAC and BRAF V600E gene mutation detection holds an exceptional diagnostic value in the preoperative diagnosis of thyroid nodules. This approach not only elevates diagnostic sensitivity and accuracy, but also deserves clinical promotion.
