Effect of neuroglial calcium signaling on neurological impairment in ischemic stroke
10.3969/j.issn.1000-4718.2023.00.004
- VernacularTitle:神经胶质细胞钙信号对缺血性脑卒中所致神经功能损伤的影响
- Author:
Yujie CHEN
1
;
Lei WANG
;
Chen ZHENG
Author Information
1. 遵义医科大学珠海校区生理学教研室,广东 珠海 519041
- Keywords:
neuroglia;
astrocyte;
calcium signaling;
ischemic stroke
- From:
Chinese Journal of Pathophysiology
2024;40(3):551-556
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is one of the leading causes of disability and death in China,but its mechanism has not been thoroughly elucidated.As an important class of cells in maintaining neurological homeostasis,the intracellular calcium signaling of glial cells plays a dual role in mitigating and exacerbating neuronal damage in stroke and largely determines the progression and outcome of stroke.In this review of the literature,focusing on astrocytes,which account for the largest proportion of glial cells,we review the mechanism of glial calcium signaling after stroke and its effect on post-stroke neuro-logical function,to provide reference for post-stroke neuroprotection and repair.
