Progress in role of intercellular mitochondrial transfer in diabetes and its complications
10.3969/j.issn.1000-4718.2023.12.016
- VernacularTitle:细胞间线粒体转移在糖尿病及其并发症中作用的研究进展
- Author:
Haiyan WANG
1
;
Wenting SONG
;
Meng ZHAO
;
Dong WANG
;
Xiaolei WANG
;
Qiu LI
Author Information
1. 山东第一医科大学附属省立医院内分泌与代谢病科,山东 济南 250021
- Keywords:
mitochondrial transfer;
diabetes mellitus;
diabetes complications;
mitochondrial transplantation
- From:
Chinese Journal of Pathophysiology
2023;39(12):2251-2258
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and has become a com-mon chronic disease worldwide.Mitochondria play key roles in energy production,signal transduction and apoptosis.Mi-tochondrial dysfunction is an important factor that promotes the development of diabetes and its complications.Maintaining mitochondrial function is expected to have a therapeutic effect on diabetes and its complications.Mitochondria can be transferred between cells,replacing dysfunctional mitochondria with exogenous healthy mitochondria and thereby reversing cell damage.Mitochondrial transfer through actin-based tunnel nanotubes,extracellular vesicles,connexins,cell fusion and extrusion has been shown to restore the bioenergetics of damaged mammalian cells.In addition,mitochondrial trans-plantation,which is an innovative strategy to treat mitochondrial diseases by increasing and replacing mitochondria,has at-tracted increasing attention.This article focuses on improving mitochondrial function in damaged cells as an entry point for the treatment of diabetes and its complications,focusing on the role of mitochondrial transfer among cells in diabetes and its complications.
