Pharmaceutical Practice of Acute Renal Injury Induced by Interaction Between Voriconazole and Nifedipine:A Case Report

VernacularTitle:1例伏立康唑与硝苯地平相互作用致急性肾损伤的药学实践
Author: Chunyan ZHANG ¹ ; Xiaolei REN ; Xiaohong ZHANG
Author Information

1. 北京大学人民医院药学部,北京 100044
Keywords: Voriconazole; Nifedipine; Interaction; Acute renal injury
From: Herald of Medicine 2024;43(4):636-638
CountryChina
Language:Chinese
Abstract: Objective To explore the mechanism and management of acute kidney injury induced by the interaction be-tween voriconazole and nifedipine.Methods A patient with acute kidney injury was treated with nifedipine controlled-release tablets and voriconazole tablets at the same time.Pharmacists analyzed drug interactions and drug characteristics during diagnosis and treatment and proposed treatment recommendations,discontinued suspected drugs(cefotaxime and voriconazole),and deter-mined subsequent treatment based on the analysis results.Results The doctor accepted the advice and the patient gradually re-covered from acute kidney injury.Conclusion Drug-drug interactions,especially those based on the interaction of liver drug enzyme CYP450,should be paid attention to in clinical diagnosis and treatment,to improve efficacy and reduce adverse reactions.