Correlation of ncRNA-mediated Up-regulation of EphB4 with Poor Prognosis and Tumor Immunoinfiltration in Low-grade Glioma
10.11969/j.issn.1673-548X.2024.02.028
- VernacularTitle:ncRNA介导的EphB4上调与低级别胶质瘤不良预后及肿瘤免疫浸润的相关性
- Author:
Zheng WU
1
;
Zhiwei REN
;
Runshi GAO
Author Information
1. 100053 北京,首都医科大学宣武医院功能神经外科
- Keywords:
Low-grade glioma;
Erythropoietin-producing human hepatocellular receptors B4;
Non-coding RNA;
Immunoinfil-tration;
Poor prognosis
- From:
Journal of Medical Research
2024;53(2):143-150,177
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of erythropoietin-producing human hepatocellular receptors B4(EphB4)and its upstream targets as well as correlation with prognosis in low-grade glioma(LGG),for analyzing its potential role as a therapeutic tar-get.Methods Firstly analyzed the expression of EphB4 in glioma and normal brain tissue by The Cancer Genome Atlas(TCGA)data-base.Then,Gene Expression Profiling Interactive Analysis(GEPIA)database was used to analyze the effects of EphB4 on various cancer survival.The possible upstream regulatory non-coding RNA(ncRNA)of EphB4 were analyzed by R and starBase database.The correla-tion of EphB4 with tumor immune cell infiltration,biomarkers of immune cells and immune checkpoint expression were analyzed using the Tumor Immune Estimation Resource(TIMER)database.Results UBA6-AS1/hsa-miR-346 axis was the most potential upstream non-coding RNA(ncRNA)related pathway to influence expression of EphB4 in LGG.At the same time,the level of EphB4 was posi-tively correlated with the tumor immune cell infiltration,immune cell biomarkers and immune checkpoint in LGG.Conclusion NcRNA-mediated up-regulation of EphB4 is associated with poor prognosis and tumor immunoinfiltration in LGG.
