Correlation Analysis of Pan-immune Inflammatory Value with Clinicopathological Characteristics and Prognostic of Breast Cancer
10.11969/j.issn.1673-548X.2023.12.032
- VernacularTitle:泛免疫炎症值与乳腺癌临床病理特征及预后相关性分析
- Author:
Na WANG
1
;
Lili GONG
;
Chunmei YE
Author Information
1. 430014 华中科技大学同济医学院附属武汉儿童医院、武汉市妇幼保健院乳腺外科
- Keywords:
Breast neoplasms;
Pan-immune inflammatory value;
Pathology;
Prognosis;
Disease-free survival
- From:
Journal of Medical Research
2023;52(12):161-165,176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between pan-immune inflammatory values(PIV)and clinicopathological char-acteristics of breast cancer patients,and analyze its value in predicting prognosis.Methods The case data of 107 patients with breast cancer admitted to Wuhan Maternal and Child Healthcare Hospital from August 2017 to August 2019 were retrospectively analyzed.The patients were followed up for 3 years,preoperative peripheral blood results were designated as cohort 1 and peripheral blood results ob-tained between 2 and 3 years after postoperative adjuvant therapy were designated as cohort 2;the optimal cut-off values for PIV were de-termined using receiver operator characteristic curve(ROC curve)for cohort 1 and cohort 2,respectively,and 107 patients were divided into PIV high-value group and PIV low-value group,and pathological characteristics were compared and analyzed between groups.Uni-variate analysis was performed and survival curves were plotted by Kaplan-Meier method and Log-rank test to analyze the value of PIV in evaluating the prognosis of breast cancer patients.Results The preoperative PIV was related to tumor size,TNM stage,vascular inva-sion,histological grade,systemic immune-inflammation index before and after operation and systemic inflammation response index(SI-RI)before operation(P＜0.05),and the postoperative PIV was significantly related to lymph node metastasis,TNM stage,histological grade,SII before and after operation and SIRI before and after operation(P＜0.05).TNM stage and histological grade in the patients of PIV high-value group were higher than those of PIV low-value group,overall survival(OS)and disease-free survival(DFS)were lower than those of PIV low-value group.Conclusion The postoperative PIV can be a predictor of OS and DFS in patients with breast cancer,the preoperative PIV can not be an independent factor for predicting OS in patients with breast cancer,but can be a predictor of DFS.
