Correlation between the Expression of Ang-2,LYVE-1 and the Biological Characteristics of Cutaneous Squamous Cell Carcinoma
10.11969/j.issn.1673-548X.2023.12.012
- VernacularTitle:Ang-2、LYVE-1的表达与皮肤鳞状细胞癌生物学特性的相关性
- Author:
Kuang LU
1
;
Zhixin YAN
Author Information
1. 212000 镇江,江苏大学附属医院整形外科
- Keywords:
Cutaneous squamous cell carcinoma;
Angiopoietin-2;
Microlymphatic vessel density;
Lymphatic vessel endothelial hyaluronan receptor-1;
Tumor metastasis
- From:
Journal of Medical Research
2023;52(12):49-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expression of angiopoietin-2(Ang-2),lymphatic vessel endo-thelial hyaluronan receptor-1(LYVE-1)and the biological characteristics of cutaneous squamous cell carcinoma.Methods A total of 44 patients with primary cSCC admitted to the Affiliated Hospital of Jiangsu University from September 2013 and February 2021 were in-cluded.The expression levels of Ang-2 and LYVE-1 in their cSCC specimens was detected by immunohistochemistry(IHC).The ex-pression level of LYVE-1 was expressed by the microlymphatic vessel density(MLVD).Results The high expression rate of Ang-2 in cSCC group without lymph node metastasis was 44％(15/34),which was significantly lower than that in CSCC group(90％,9/10),and the difference was statistically significant(P＜0.05).The high expression rate of Ang-2 in the highly differentiated cSCC group was 35％(9/26),which was significantly lower than that in the medium and poorly differentiated CSCC group(83％,15/18),and the differ-ence was statistically significant(P＜0.05).The expression of LYVE-1 in cSCC group without lymph node metastasis was 8.49±4.26,which was significantly lower than that in cSCC group(13.48±5.91),and the difference was statistically significant(P＜0.05).The expression of LYVE-1 in highly differentiated cSCC group was 6.39±2.09,which was significantly lower than that in medium and poor-ly differentiated cSCC group(14.28±4.42),and the difference was statistically significant(P＜0.05).The expression of Ang-2 and LYVE-1 was not related to gender,age and tumor size(P＞0.05).The expression level of Ang-2 was positively correlated with LYVE-1(r=0.598,P＜0.01).Conclusion Ang-2 and LYVE-1 are involved in promoting the occurrence,development and lymph node metastasis of cSCC.
