Clinical applications of preservative-free intraocular pressure-lowering drugs: the future prospects
10.3760/cma.j.cn115989-20230419-00141
- VernacularTitle:不含防腐剂的降眼压药物应用前景
- Author:
Jingjing HUANG
1
;
Jian GE
Author Information
1. 中山大学中山眼科中心 眼病防治全国重点实验室 广东省眼科视觉科学重点实验室，广州 510060
- Keywords:
Glaucoma;
Intraocular pressure;
Drug therapy;
Preservative-free;
Advances;
Future prospects
- From:
Chinese Journal of Experimental Ophthalmology
2023;41(12):1231-1236
- CountryChina
- Language:Chinese
-
Abstract:
Long-term use of topical intraocular pressure-lowering medications, particularly those containing preservatives, may cause or worsen ocular surface diseases, which may ultimately reduce patient tolerance and compliance, increase surgical risk, and compromise treatment efficacy.Therefore, long-term management of glaucoma requires the consideration of various factors such as efficacy, safety, and cost-effectiveness.Recently, the use of preservative-free (PF) intraocular pressure-lowering drugs has been gaining considerable attention in research as a means to avoid the toxicity of preservatives on ocular health.These drugs have similar pharmacokinetic properties and bioequivalence to their corresponding preservative-containing drugs.In addition, the manufacturing process of PF medications can reduce the incidence of ocular surface diseases, improve patient symptoms, and increase treatment effectiveness, indicating extensive potential applications.This review focuses on the development and clinical use of PF intraocular pressure-lowering drugs, aiming to deepen clinicians' understanding of their use.
