Recent advances in biological therapy of diabetic retinopathy
10.13389/j.cnki.rao.2024.0062
- VernacularTitle:糖尿病视网膜病变的生物治疗研究最新进展
- Author:
Duo LI
1
;
Xiaoyan HAN
;
Qin JIANG
Author Information
1. 210029 江苏省南京市,南京医科大学附属眼科医院
- Keywords:
diabetic retinopathy;
biological therapy;
immunotherapy;
targeted therapy;
gene therapy;
cell therapy
- From:
Recent Advances in Ophthalmology
2024;44(4):317-323
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is one of the most common fundus vascular diseases and a leading cause of blindness in adults of working age.The occurrence and development of DR involves a variety of pathophysiologic mecha-nisms,including metabolic dysregulation,oxidative stress,inflammation,and neurovascular unit hypofunction.Conven-tional clinical treatments,such as anti-vascular endothelial growth factor drugs and retinal laser photocoagulation,have long treatment cycles and variable outcomes in some patients and sometimes require vitrectomy in the later stages of the disease.With the in-depth research on the molecular level of the pathogenesis of DR,a number of biological therapeutic modalities,such as targeted therapy,gene therapy,immunotherapy and cell therapy,have received more and more atten-tion from researchers.This review summarizes the biologic therapeutic modalities currently available for DR and outlines the benefits and limitations of these approaches with a view to informing researchers.
